From the airport :

1. Buy a ticket (60 min / 0,7 € = interchange ticket)
2. Get on bus No. 61 (direction Hlavná stanica)
3. Get off at „Trnavské mýto“
4. Change to tram No. 1 (direction Pri Kríži), or No. 4 (direction Karlova Ves), or No. 9 (direction Karlova Ves)
5. Get off at „Mariánska“
6. Walk straight ahead on Špitálska street towards centre, cca 100m adn you will see the hotel in front of you